Alkyl Halides
Medchemexpress LLC Bromo-PEG8-bromide | 2376383-09-2 | 98.0% | 540.28 g/mol | C18H36Br2O8 | 100 MG
Bromo-PEG8-bromide is a bromo-terminated polyethylene glycol (PEG8) linker used as a bifunctional reagent in bioconjugation and drug-delivery research. The compound provides two terminal bromide leaving groups on an eight-unit PEG chain, enabling nucleophilic substitution reactions for linker assembly and PEGylation to modify solubility and pharmacokinetics.
- Bromo-terminated PEG8 linker for bioconjugation.
- Suitable for thiol and amine alkylation reactions.
- Enables PEGylation to improve solubility and circulation time.
- Available in small research pack sizes (e.g., 100 mg).
- High purity (98%) appropriate for research applications.
Medchemexpress LLC Perfluorododecanoic acid | 307-55-1 | MFCD00198081 | 95.0% | 614.10 g·mol⁻¹ | C12HF23O2 | 10 MG
Perfluorododecanoic acid is a perfluoroalkyl carboxylic acid used as a research reagent to investigate PFAS-driven biological effects such as cytotoxicity, increased reactive oxygen species, and altered mitochondrial membrane potential. It is provided as a high-purity solid for laboratory studies.
eMolecules 1186194-98-8 | 2,4-dichloro-3-(trifluoromethyl)pyridine | Key Organics/BIONET | MFCD12547046 | 215.980 | C6H2Cl2F3N | 97.000 | FC(F)(F)c1c(Cl)ccnc1Cl | 10mg | 564136012
2,4-dichloro-3-(trifluoromethyl)pyridine | Key Organics/BIONET | 1186194-98-8 | MFCD12547046 | 215.980 | C6H2Cl2F3N | 97.000 | FC(F)(F)c1c(Cl)ccnc1Cl | 10mg | 564136012
Medchemexpress LLC 2-Methylpropane-2-sulfinamide | 146374-27-8 | 98.0% | 121.20 | 25 G
2-Methylpropane-2-sulfinamide is an amide compound that can be utilized as an intermediate in pharmaceutical synthesis.
- Can be used in the synthesis of 4-sulfonimidoylpiperidine.
- Reacts with benzyl Grignard reagent to form 4-benzyl-4-aminopiperidine, which is an important pharmaceutical building block.
- Can be applied to insert a methylene group into derivatized sulfonimides for the preparation of spiro-tosylaziridines.
Medchemexpress LLC X-376 | 1365267-27-1 | 98.1% | 547.41 g·mol⁻¹ | C25H25Cl2FN6O3 | 10 MG
X-376 is a small-molecule tyrosine kinase inhibitor that potently targets anaplastic lymphoma kinase (ALK) and shows inhibitory activity against MET. It is supplied as a powder for preclinical research use and is suitable for cellular and in vivo studies of ALK-driven tumors.
- Potent ALK inhibition (IC50 0.61 nM).
- MET inhibitory activity (IC50 0.69 nM).
- Suitable for preclinical cellular and in vivo research.
- Supplied as a powder with recommended cold storage for stability.
- Molecular weight 547.41 g·mol⁻¹; formula C25H25Cl2FN6O3.
Medchemexpress LLC Perfluoropentanoic acid | 2706-90-3 | 98.0% | 264.05 | 25 G
Perfluoropentanoic acid (PFPeA) is a short-chain perfluorinated compound that serves as an important indicator of perfluorinated compound pollution in ecosystems. It has been observed to affect planktonic microbial communities and show certain toxicity in mice studies.
- Indicator of perfluorinated compound pollution
- Impacts planktonic microbial communities
- Can threaten water quality via microbial metabolism
- In vivo studies suggest potential for liver damage and skin inflammation
eMolecules 159635-50-4 | N-Boc-n,n-bis(2-bromoethyl)amine | Combi-Blocks | MFCD11519276 | 331.048 | C9H17Br2NO2 | 98.000 | CC(C)(C)OC(=O)N(CCBr)CCBr | 10g | 415497438
N-Boc-n,n-bis(2-bromoethyl)amine | Combi-Blocks | 159635-50-4 | MFCD11519276 | 331.048 | C9H17Br2NO2 | 98.000 | CC(C)(C)OC(=O)N(CCBr)CCBr | 10g | 415497438
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.59% | 400.35 | 50 MG
BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). For research use only; not sold to patients.
- Orally bioavailable
- Highly potent and selective inhibitor of human neutrophil elastase (HNE)
- Cell-permeable
- IC50 of 20 nM (HNE)
- Ki value for MNE is 700 nM
- Fourth-generation HNE inhibitor
- More than 2,000-fold selectivity in a panel of 21 serine proteases
- Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action
- Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice
Medchemexpress LLC Bromo-PEG2-bromide | 31255-10-4 | 99.25% | 1 G
Bromo-PEG2-bromide is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product has a molecular weight of 275.97 and a chemical formula of C6H12Br2O2, appearing as a colorless to light yellow liquid with a density of 1.6777 g/cm3.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
- Colorless to light yellow liquid appearance
- Molecular weight of 275.97
- Chemical formula: C6H12Br2O2
- Density of 1.6777 g/cm3
Medchemexpress LLC Beperidium iodide | 86434-57-3 | MFCD00866899 | 100.0% | 527.44 g/mol | C23H34IN3O3 | 5 MG
Beperidium iodide is the iodide salt of a bioactive compound used as a competitive antagonist of acetylcholine receptors. It is supplied as a small, high-purity research reagent with a reported pA2 of 7.93, intended for use as a pharmacological probe in studies of cholinergic signaling.
- Competitive antagonist of acetylcholine receptors with reported pA2 = 7.93.
- High purity (99.97%) suitable for analytical and experimental use.
- Molecular formula C23H34IN3O3 and molecular weight 527.44 g/mol.
- Available as a 5 mg research pack for laboratory studies.
- Provided as the iodide salt for improved stability and handling.